GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION

BIOLOGY OF VASCULAR SYSTEM/FRL-6020

Course Title:	BIOLOGY OF VASCULAR SYSTEM
Credits	2	ECTS	6
Course Semester	3	Type of The Course	Elective

COURSE INFORMATION

-- (CATALOG CONTENT)

-- (TEXTBOOK)

-- (SUPPLEMENTARY TEXTBOOK)

-- (PREREQUISITES AND CO-REQUISITES)

-- LANGUAGE OF INSTRUCTION

Turkish

-- COURSE OBJECTIVES

-- COURSE LEARNING OUTCOMES

To explain general principles and mechanics of cardiovascular system.
To explain the components of vascular cell biology and pharmacological interventions.
To explain the ion channels, their function and role in blood pressure regulation.
To explain the growth factors, angiogenesis and their pharmacodynamics.
To define vasoactive mediators and their action mechanisms.
To define the endothelial cell functions, pathogenesis and nitric oxide cell signaling.
To define vascular metabolic disease: hypertension, atherosclerosis and related drug interventions.
To define blood elements-vessel wall interactions, thrombosis and antitrombotic agents.
To discuss the in vitro and in vivo pharmacological methods for measurement of vascular cell and tissue functions.
To explain vascular remodeling, vascular inflammation, immunity and new drug targets.

-- MODE OF DELIVERY

The mode of delivery of this course is Face to face.

--WEEKLY SCHEDULE
1. Week	Current prospects in vascular biology, pharmacology and medicine.
2. Week	Smooth muscle contractile mechanisms and role of intracellular and extracellular calcium.
3. Week	Intracellular calcium stores, exchance mechanisms, channels, agonists and antagonists.
4. Week	Molecular aspects of endothelial mediators and mechanisms of its interaction with vascular smooth muscle.
5. Week	Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases.
6. Week	Endothelial injury in the initiation and progression of vascular disorders.
7. Week	The inflammatory response is a natural defensive reaction of vessels to injury or infection and associated drugs.
8. Week	Activation, adhesion and aggregation of platelets; pletelet inhibitors and related action mechanisms.
9. Week	Antiplatelet drug targets. ADP receptor antagonists. Phosphodiesterase inhibitors. Fibrinogen receptor antagonists. NSAID’s. Thrombin inhibitors.
10. Week	Pharmacology of hypertension and the treatment of hypertension: Calcium channel blockers, ACE inhibitors and vasodilators.
11. Week	Pharmacology of hypertension and the treatment of hypertension: Diuretics, drugs affecting the sympathetic nervous system.
12. Week	Targeting NADPH oxidases in vascular pharmacology.
13. Week	Blood Clotting and anti-coagulation therapies.
14. Week	Role of oxidative stress in diabetes-mediated vascular dysfunction: Unifying hypothesis of diabetes revisited.
15. Week	Vascular pharmacology of ATP-sensitive K+ channels: interactions between sulphonylureas and K+ channel openers.
16. Week	The in vitro and in vivo pharmacological methods for measurement of vascular cell and tissue functions.

-- TEACHING and LEARNING METHODS

-- ASSESSMENT CRITERIA

	Quantity	Total Weighting (%)
Midterm Exams	1	40
Assignment	1	20
Application	0	0
Projects	0	0
Practice	0	0
Quiz	0	0

Percent of In-term Studies		60
Percentage of Final Exam to Total Score		40

-- WORKLOAD

Activity	Total Number of Weeks	Duration (weekly hour)	Total Period Work Load
Weekly Theoretical Course Hours	14	2	28
Weekly Tutorial Hours			0
Reading Tasks	14	3	42
Searching in Internet and Library	14	3	42
Material Design and Implementation			0
Report Preparing			0
Preparing a Presentation	2	3	6
Presentation	1	1	1
Midterm Exam and Preperation for Midterm Exam	7	1	7
Final Exam and Preperation for Final Exam	14	2	28
Other (should be emphasized)			0
TOTAL WORKLOAD:			154
TOTAL WORKLOAD / 25:			6.16
Course Credit (ECTS):			6

-- COURSE'S CONTRIBUTION TO PROGRAM

NO	PROGRAM LEARNING OUTCOMES	1	2	3	4	5
1				X
2					X
3				X
4				X
5				X
6					X
7					X
8				X
9						X
10						X
11				X
12				X
13					X
14				X

-- NAME OF LECTURER(S)

(Assoc.Prof. Sevil ÖZGER İLHAN)

-- WEB SITE(S) OF LECTURER(S)

(http://www.websitem.gazi.edu.tr/site/soilhan)

-- EMAIL(S) OF LECTURER(S)

(soilhan@gazi.edu.tr)

Gazi University

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GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR