GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
DISSOLUTION RATE AND THE RELEASE KINETIC FROM DOSAGE FORMS-PRACTICE/FTE-2171
Course Title: DISSOLUTION RATE AND THE RELEASE KINETIC FROM DOSAGE FORMS-PRACTICE
Credits 2 ECTS 7
Semester 1 Compulsory/Elective Elective
COURSE INFO
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- NAME OF LECTURER(S)
  Assoc.Prof.Zeynep Şafak TEKSİN, Assoc.Prof.Tuba İnceçayır
 -- WEB SITE(S) OF LECTURER(S)
  http://websitem.gazi.edu.tr/site/zsteksin, http://www.websitem.gazi.edu.tr/site/tincecayir
 -- EMAIL(S) OF LECTURER(S)
  zsteksin@gazi.edu.tr, tincecayir@gazi.edu.tr
 -- LEARNING OUTCOMES OF THE COURSE UNIT
Understanding the fundamentals and basic concepts of dissolution and dissolution kinetics
Learning comparison of dissolution profiles
Learning experimental design of dissolution






 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 -- PREREQUISITES AND CO-REQUISITES
  There is no prerequisite or co-requisite for this course.
 -- RECOMMENDED OPTIONAL PROGRAMME COMPONENTS
  There is no recommended optional programme component for this course.
 --COURSE CONTENT
1. Week  The importance of dissolution in Pharmaceutical Technology
2. Week  Enhancement of solubility, problems in dissolution experiments and solutions
3. Week  Dissolution apparatus in Pharmacopeİa
4. Week  Intrinsic dissolution
5. Week  Wetting of powders and evaluation of kinetics
6. Week  Validation of dissolution equipments and test optimization
7. Week  Evaluation of dissolution profiles
8. Week  Dissolution kinetics (Hixon-Crowell equation, Kitozawa equation)
9. Week  Dissolution kinetics (Dankwerts model, Weibull model)
10. Week  Dissolution kinetics (RRSBW, El Yazigi, Peppas)
11. Week  Biorelevant dissolution media
12. Week  Dissolution studies based on USP and European Pharmacopeİa method from solid dosage forms
13. Week  Dissolution studies based on USP and European Pharmacopeİa method from solid dosage forms
14. Week  Comparison of dissolution profiles (f1 nad f2 tests)
15. Week  
16. Week  
 -- RECOMMENDED OR REQUIRED READING
  Encyclopedia of Pharmaceutical Technology, (Ed: Swarbrick, J., Boylan, J.C.), Vol.3., Marcel and Dekker, New York and Basel, 1992.
 -- PLANNED LEARNING ACTIVITIES AND TEACHING METHODS
  Lecture, Question & Answer, Demonstration, Drill - Practise
 -- WORK PLACEMENT(S)
  -
 -- ASSESSMENT METHODS AND CRITERIA
 
Quantity
Percentage
 Mid-terms
0
0
 Assignment
1
10
 Exercises
1
50
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Contribution of In-term Studies to Overall Grade  
60
 Contribution of Final Examination to Overall Grade  
40
 -- WORKLOAD
 Efficiency  Total Week Count  Weekly Duration (in hour)  Total Workload in Semester
 Theoretical Study Hours of Course Per Week
0
0
0
 Practising Hours of Course Per Week
14
2
28
 Reading
8
6
48
 Searching in Internet and Library
8
6
48
 Designing and Applying Materials
0
0
0
 Preparing Reports
4
4
16
 Preparing Presentation
4
4
16
 Presentation
2
2
4
 Mid-Term and Studying for Mid-Term
1
7
7
 Final and Studying for Final
1
8
8
 Other
0
 TOTAL WORKLOAD: 
175
 TOTAL WORKLOAD / 25: 
7
 ECTS: 
7
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1Posesses extensive knowledge accumulation on the field of Pharmaceutical Technology, learns pre-formulations of all pharmaceutical dosage forms, formulation designs and in vitro/in vivo evaluations of formulations.X
2Gains the capability of following up novalities in technology, and posesses the capability of literature search, evaluation and interpretation on the fields of Pharmacy.X
3Gains the capability of patent search and evaluation and patenting regarding the formulations of active drug ingredient, dosage forms and preparation technologies.X
4Learns sufficient knowledge on the the field of laboratory, pilot batch and industrial scale productions, quality controls, quality assurance system, good manufacture practice (GMP) and stability assurance of all dosage forms.X
5Learns the knowledge satisfying the capability level for designing original and generic drugs, evaluating process validation and quality assurance.X
6Learns the interpretation, statistical evaluation and practical application of the research results.X
7Posesses the knowledge on new drug delivery systems and posesses the knowledge and capacity on targetting these systems at a level of an expert.X
8Learns designing, formulations, preparation techniques, physical and chemical stabilities of biotechnological products.X
9Gains the capability of finding solutions to the problems encountered during research. He/she gains the capability of analytical thinking. He/she gains the capability of publishing the experimental results in the national/international journals.X
10Gains the capability of following and interpretion of important wold health organizations (FDA, EMA, ICH and WHO) and official reference books (pharmacopoeia etc.). As a result, he/she transfers his/her knowledge to the field of Pharmaceutical Technology, and develops new approaches.X