GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
DRUG RECEPTOR INTERACTIONS AND SIGNAL TRANSDUCTION MECHANISMS-II/FRL-4060
Course Title: DRUG RECEPTOR INTERACTIONS AND SIGNAL TRANSDUCTION MECHANISMS-II
Credits 2 ECTS 6
Course Semester 2 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Students should define the advanced mechanisms in intracellular communications,
Students should explain the abnormalities in advanced mechanisms of intracellular signal transductions,
Students should discuss the recently described intracellular signalling mechanisms with their targeted drug molecules,
Students should understand the alterations in advanced intracellular signaling molecules at disease states.
Students should discuss nuclear receptors/steroid receptors signalling with their physiology and pathology,
Students should discuss integrin-receptors, integrin-signalling, integrin-linked kinases,
Students should describe the metabolism, calcium current, redox balance and drugs related with mitochondria and endoplasmic reticulum homeostasis,
Students should describe apoptotic pathways, caspases ,MAP kinase, ERK pathway, TGF beta kinase,NF-kappa B, JAK/STAT pathways,
Students should describe PI3K/Akt/mTOR pathway, calorie restriction, otofagia, longevity concept and the relation with each other,
Students should discuss the importance of redox signalling and related molecules, and NO pathway in patophysiology and related drugs with these system

 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face.
 --WEEKLY SCHEDULE
1. Week  General view to advanced mechanisms to intracellular cell signalling,
2. Week  Nuclear Receptors & cell signalling
3. Week  Molecular Pharmacology of Protein Kinases (and Phosphatases): Molecules, mechanisms, medicines
4. Week  Ligand-Gated Ion Channels
5. Week  Cytokine Receptors and Jak-STAT Signaling
6. Week  Cancer Biology & Cell Signaling
7. Week  Protein Modification in Signaling (Intracellular Signaling addressed posttranslational modification of proteins and their consequences)
8. Week  Molecular Pharmacology of Protein Kinases. Signaling addressed protein kinase structure, conformational changes, molecular domains, activation/inhibit
9. Week  Na/K-ATPase and Its Role in Signal Transduction (Intracellular Signaling addressed Na/K-ATPase as a receptor)
10. Week  Signalling in platelets: Role of PKC isoforms in platelet function and thrombosis
11. Week  The role of oxidant-mediated signaling in growth factor- and drug-related inhibition of tumor cell proliferation
12. Week  Elucidates the relationship of the cellular networks/pathways and the cell-responses to Chemotherapeutic agents,proposes novel therapeutic strategies
13. Week  The TOR signaling network:Aging, longevity and TORC1 activity,
14. Week  Relationship between Insulin/insulin-like growth factor 1 signaling molecules and longevity include DAF-2 and InR and their homologues in mammals,
15. Week  Not available
16. Week  Not available
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
20
 Assignment
1
10
 Application
0
0
 Projects
1
5
 Practice
0
0
 Quiz
1
5
 Percent of In-term Studies  
40
 Percentage of Final Exam to Total Score  
60
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
2
28
 Weekly Tutorial Hours
0
 Reading Tasks
14
2
28
 Searching in Internet and Library
14
2
28
 Material Design and Implementation
0
 Report Preparing
0
 Preparing a Presentation
6
2
12
 Presentation
6
1
6
 Midterm Exam and Preperation for Midterm Exam
7
2
14
 Final Exam and Preperation for Final Exam
7
2
14
 Other (should be emphasized)
10
2
20
 TOTAL WORKLOAD: 
150
 TOTAL WORKLOAD / 25: 
6
 Course Credit (ECTS): 
6
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X
11X
12X
13X
14X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Çimen KARASU and other faculty members in our department)
 -- WEB SITE(S) OF LECTURER(S)
   (www.cimenkarasu.org)
 -- EMAIL(S) OF LECTURER(S)
   (Cimen Karasu Zafer Güney Canan Uluoglu , sevil ilhan , Süreyya BARUN , Ergin Dilekoz , Gokce Ozturk )