GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
DRUG RECEPTOR INTERACTIONS AND SIGNAL TRANSDUCTION MECHANISMS-I/FRL-3010
Course Title: DRUG RECEPTOR INTERACTIONS AND SIGNAL TRANSDUCTION MECHANISMS-I
Credits 3 ECTS 9
Course Semester 1 Type of The Course Compulsory
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
To define principles and philosophy of cell to cell and intracellular communications,
To define receptor's types, general regulation of receptor macromolecules and receptor-ligand interactions,
To define what is endogenous and exogenous ligands and fuels of cells and drugs for the receptors,
To discuss generally the kinetics of receptor-ligand interaction and factors changing these interactions and cellular effects,
To explain and discuss what is the principles of post-receptor signaling and cascades chancing cellular response and effects,
Students should illustrate and discuss membrane-bound receptor interactions and alterations in membrane macromolecules,
Students should explain and discuss G proteins, effector macromolecules, second messengers, tyrosine kinase coupled receptor interactions,
To define advanced themes in G-protein coupled receptors signalling and related transduction molecules in different cell types,
To explain and discuss the general roles of intracellular organelles in intracellular signalling systems,
To define advanced consideration of cellular signal transduction pathways regulating cell differentiation, cell viability and cell death,
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  Biology, principles and philosophy of cell to cell and intracellular communications,
2. Week  The receptor types; the factors affecting sythesis and the regulation of receptor macromolecules,
3. Week  The mode of receptor-ligand interactions and affecting factors, which changes these interactions,
4. Week  Exogenous and endogenous ligands; evaluation of affinity of receptors to ligands in the axis from nutrients-fuels to drugs,
5. Week  Receptor-Ligand interaction modes; the factors changing Receptor-Ligand interactions; Ligands as agonist or antagonist,
6. Week  The factors altering the kinetics of Receptor-Ligand interactions,
7. Week  The factors altering the kinetics of Receptor-Ligand interactions and changing cellular response to drugs,
8. Week  The biology of membrane receptors and their ligands,
9. Week  G protein-coupled receptor (GPCR) signaling and enzyme-linked receptor activation: GPCR trafickking
10. Week  Second messengers as signalling molecules and effecting drugs,
11. Week  Post-receptor signalling of G-protein coupled receptors: Models according to the cell types and ligands,
12. Week  Defects in G-protein coupled receptors interactions and altered cellular response,
13. Week  Receptor tyrosine kinases are the high-affinity cell surface receptors for polypeptide growth factors, cytokines and hormones:physiology and pathology
14. Week  Peptide Ligands and their signal transduction pathways: pathology and drugs,
15. Week  Not Available
16. Week  Not Available
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
20
 Assignment
1
10
 Application
0
0
 Projects
1
5
 Practice
0
0
 Quiz
1
5
 Percent of In-term Studies  
40
 Percentage of Final Exam to Total Score  
60
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
 Reading Tasks
14
3
42
 Searching in Internet and Library
14
3
42
 Material Design and Implementation
0
 Report Preparing
0
 Preparing a Presentation
6
3
18
 Presentation
6
1
6
 Midterm Exam and Preperation for Midterm Exam
7
3
21
 Final Exam and Preperation for Final Exam
7
3
21
 Other (should be emphasized)
11
3
33
 TOTAL WORKLOAD: 
225
 TOTAL WORKLOAD / 25: 
9
 Course Credit (ECTS): 
9
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X
11X
12X
13X
14X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Çimen KARASU and other faculty members in our department)
 -- WEB SITE(S) OF LECTURER(S)
   (www.cimenkarasu.com)
 -- EMAIL(S) OF LECTURER(S)
   (Cimen Karasu Zafer Güney Canan Uluoglu , sevil ilhan , Süreyya BARUN , Ergin Dilekoz , Gokce Ozturk )