GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
GENOTOXICITY/FTO-3080
Course Title: GENOTOXICITY
Credits 3 ECTS 7.5
Course Semester 1 Type of The Course Compulsory
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
The ability to conduct toxicology researches, evaluate and interpret experimental results
The ability to effectively use laboratory skills acquired in toxicological researches
The ability to perform comprehensive toxicological data analysis, analyze new ideas, synthesize and evaluate
The demonstrate excellence and innovation in problem-solving skills, interpreting intellectual level, and high level oral and written communication sk
The ability to evaluate and apply the health risks of drugs and other chemical substances in human-.Chemical risk assessment skills
Gain the ability to understand the mechanisms of action of carcinogenic and mutagenic agents
To learn the principles of application and evaluation of toxic effects of chemical agents in in vivo and in vitro test systems
Gain the ability to understand the role of target organs in the toxic effects of drugs and other chemicals
Ability to monitor and investigate adverse effects of drugs
The ability to analyze the molecular and cellular effects of chemicals and radiation on male and female reproductive systems and developing embryo / f
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to fac
 --WEEKLY SCHEDULE
1. Week  Definition of genotoxicity and types of DNA damage
2. Week   Microlesions and .the bacterial reverse mutation test Salmonella/microsome assay )
3. Week   Macrolesions and cytologically visible tests
4. Week   Chromosomes structure and detection
5. Week   Numerical chromosome changes
6. Week   Structural chromosomal changes
7. Week   Chromosome aberrations and their significance in genotoxicity tests
8. Week   Sister chromatid exchange
9. Week   Comet assay (Single cell gel electrophoresis technique) 1
10. Week  Micronucleus and examples from other short term genotoxicity assays
11. Week   Quantification of short term tests
12. Week   Clinical application of short term tests
13. Week   Biomonitoring with short term tests
14. Week   Advantages and disadvantages of short term assays
15. Week  yok
16. Week  yok
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
25
 Assignment
1
25
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
 Reading Tasks
2
10
20
 Searching in Internet and Library
2
10
20
 Material Design and Implementation
0
 Report Preparing
2
10
20
 Preparing a Presentation
2
10
20
 Presentation
2
9
18
 Midterm Exam and Preperation for Midterm Exam
1
18
18
 Final Exam and Preperation for Final Exam
1
30
30
 Other (should be emphasized)
0
0
 TOTAL WORKLOAD: 
188
 TOTAL WORKLOAD / 25: 
7.52
 Course Credit (ECTS): 
7.5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X
11X
12X
13X
14X
15
 -- NAME OF LECTURER(S)
   (Prof. Bensu KARAHALİL , Assoc. Prof. Gonca ÇAKMAK)
 -- WEB SITE(S) OF LECTURER(S)
   (http://www.websitem.gazi.edu.tr/site/bensu; http://www.websitem.gazi.edu.tr/site/gcakmak)
 -- EMAIL(S) OF LECTURER(S)
   (bensu@gazi.edu.tr; gcakmak@gazi.edu.tr)