GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
SMOOTH MUSCLE CHRONOPHARMACOLOGY/TFRL-6070
Course Title: SMOOTH MUSCLE CHRONOPHARMACOLOGY
Credits 2 ECTS 6
Course Semester 3 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  English
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Learns functional properties of smooth muscles and related neuromediators
Understands the importance of biological rhythms in smooth muscle pharmacology and their effects on biological response
Gets familiar with the importance of administration time in the effect of drugs related to smooth muscle functions in experimental settings
Can use time as a standardization parameter in smooth muscle experiments
Learns rhythmic properties in synthesis and release of the endogenous vasoactive agents
Compahends the importace of synchronization of experimental animals via light-dark cycle
Learns experimental chronopharmacology of adrenergic agonists in vasculary smooth muscle preparations
Learns experimental chronopharmacology of cholinergic agonists in vasculary smooth muscle preparations
Learns experimental chronopharmacology of histaminergic and serotonergic agonists in vasculary smooth muscle preparations
Learns experimental chronopharmacology of nitrovasodilators in vasculary smooth muscle preparations

 -- MODE OF DELIVERY
  The mode of delivery of this course is face to face
 --WEEKLY SCHEDULE
1. Week  Functional properties of smooth muscles and related neuromediators
2. Week  Biological rhythms in smooth muscle tone
3. Week  Time of obtaining smooth muscle preparation as a standardisation approach
4. Week  Rhythmic properties in synthesis and release of the endogenous vasoactive agents
5. Week  Biological rhythms in the density of neurotransmitter receptors
6. Week  Biological rhythms in post-receptor mechanisms
7. Week  - Synchronization of experimental animals via light-dark cycle
8. Week  Experimental chronopharmacology of serotonin in vasculary smooth muscle preparations
9. Week  Experimental chronopharmacology of adrenergic agonists in vasculary smooth muscle preparations
10. Week  Experimental chronopharmacology of histamin in vasculary smooth muscle preparations
11. Week  Experimental chronopharmacology of acetylcholine in vasculary smooth muscle preparations
12. Week  Experimental chronopharmacology of calciun channel blockers in vasculary smooth muscle preparations
13. Week  Changes in pA2 and KD of antagonists regarding to the time of obtaining smooth muscle preparation
14. Week  Importance of preparation timing in experimental and clinical settings
15. Week  
16. Week  
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
70
 Assignment
1
20
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
1
10
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
2
28
 Weekly Tutorial Hours
0
 Reading Tasks
14
2
28
 Searching in Internet and Library
14
1
14
 Material Design and Implementation
0
 Report Preparing
0
 Preparing a Presentation
14
2
28
 Presentation
14
1
14
 Midterm Exam and Preperation for Midterm Exam
14
0
 Final Exam and Preperation for Final Exam
14
3
42
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
154
 TOTAL WORKLOAD / 25: 
6.16
 Course Credit (ECTS): 
6
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3
4X
5
6X
7
8X
9X
10
11
12
13X
14X
 -- NAME OF LECTURER(S)
   (All faculty members of the pharmacology department.)
 -- WEB SITE(S) OF LECTURER(S)
   (https://websitem.gazi.edu.tr/site/barun)
 -- EMAIL(S) OF LECTURER(S)
   (barun@gazi.edu.tr; sbarun99@hotmail.com)