GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
SIGNAL PATHWAYS/TBG-5120
Course Title: SIGNAL PATHWAYS
Credits 3 ECTS 9
Semester 1 Compulsory/Elective Elective
COURSE INFO
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- NAME OF LECTURER(S)
  Prof. Dr. Ece Konaç
 -- WEB SITE(S) OF LECTURER(S)
  http://websitem.gazi.edu.tr/site/ecem
 -- EMAIL(S) OF LECTURER(S)
   ecem@gazi.edu.tr; ecemercanoglu@yahoo.com
 -- LEARNING OUTCOMES OF THE COURSE UNIT
To learn the inter/intra cellular signal pathways
To learn the regulatory molecules in signal system
To learn the reason and consequence of defective signal systems
To learn angiogenesis
To learn molecular steps for designing anti-angiogenetic factors
Acquainted with the importance of regulation of cell signal pathways on cell survival activity
Acquainted with the importance of regulation of cell signal pathways on cell vital activity
Learns the angiogenesis regulation
Learns the molecular pathways in angiogenesis regulation and progression
Learns the effects of combination conventional cytotoxic agents and novel anti-angiogenetic approaches in targeting therapies
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 -- PREREQUISITES AND CO-REQUISITES
  There is no prerequisite or co-requisite for this course.
 -- RECOMMENDED OPTIONAL PROGRAMME COMPONENTS
  There is no recommended optional programme component for this course.
 --COURSE CONTENT
1. Week  Signal systems molecules
2. Week  Signal systems receptors
3. Week  Intracellular signal systems pathways
4. Week  Angiogenesis and tumor progression
5. Week  Molecular regulation signal pathways of angiogenesis
6. Week  Molecular relationship between hypoxia inducible factor 1 and vascular endothelial growth factor (VEGF)
7. Week  VEGF related signal pathways
8. Week  Ras-Raf-Mek-Erk signal pathways
9. Week  PI3K-Akt-mTOR signal pathways
10. Week   Mid-Term
11. Week  Wnt/β-catenin signal pathways
12. Week  Integrin, extracellular matrix protein, related signal pathways (ANGPT/Tie, MMP)
13. Week  Pro-angiogenik immün and endothelial progenitor (stem) cells and chemokins
14. Week  Anti-angiogenic treatments from present to the future, gene therapy and nanotherapeutics
15. Week  Delta like ligand-4 (Dll4)/Notch signal pathways
16. Week   Final Examination
 -- RECOMMENDED OR REQUIRED READING
  Molecular Biology of the Gene, 6th Edition, Watson, 2010. Angiogenesis. Adair TH, Montani JP., 2010. StemBook Cambridge (MA): Harvard Stem Cell Institute; 2008. Holland-Frei Cancer Medicine. 6th edition. Kufe DW, Pollock RE, Weichselbaum RR, et al., editors., 2003 Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Gen, Genetik Değişim ve Hastalıklar, Abdullah Ekmekçi, Gazi Kitabevi, Ankara 2006.
 -- PLANNED LEARNING ACTIVITIES AND TEACHING METHODS
  Lecture, Question & Answer
 -- WORK PLACEMENT(S)
  NA
 -- ASSESSMENT METHODS AND CRITERIA
 
Quantity
Percentage
 Mid-terms
1
40
 Assignment
0
0
 Exercises
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Contribution of In-term Studies to Overall Grade  
40
 Contribution of Final Examination to Overall Grade  
60
 -- WORKLOAD
 Efficiency  Total Week Count  Weekly Duration (in hour)  Total Workload in Semester
 Theoretical Study Hours of Course Per Week
16
3
48
 Practising Hours of Course Per Week
0
 Reading
15
3
45
 Searching in Internet and Library
15
3
45
 Designing and Applying Materials
0
 Preparing Reports
0
 Preparing Presentation
2
2
4
 Presentation
1
1
1
 Mid-Term and Studying for Mid-Term
9
3
27
 Final and Studying for Final
16
4
64
 Other
0
 TOTAL WORKLOAD: 
234
 TOTAL WORKLOAD / 25: 
9.36
 ECTS: 
9
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X