GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
ALTERNATIVE TOXICITYTEST METHODS/FTO-4090
Course Title: ALTERNATIVE TOXICITYTEST METHODS
Credits 3 ECTS 7.5
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
The ability to conduct toxicology researches, evaluate and interpret experimental results
The ability to effectively use laboratory skills acquired in toxicological researches
The ability to perform comprehensive toxicological data analysis, analyze new ideas, synthesize and evaluate
The demonstrate excellence and innovation in problem-solving skills, interpreting intellectual level, and high level oral and written communication sk
The ability to evaluate and apply the health risks of drugs and other chemical substances in human-.Chemical risk assessment skills
Gain the ability to understand the mechanisms of action of carcinogenic and mutagenic agents
To learn the principles of application and evaluation of toxic effects of chemical agents in in vivo and in vitro test systems
Gain the ability to understand the role of target organs in the toxic effects of drugs and other chemicals
Ability to monitor and investigate adverse effects of drugs
Ability to monitor and investigate adverse effects of drugs The ability to analyze the molecular and cellular effects of chemicals and radiation

 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  Alternative tests from current toxicity tests-transition process
2. Week  ECVAM (European Centre for the Validation of Alternative Methods) and its responsibilities on alternative tests
3. Week  ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods) and its responsibilities on alternative tests
4. Week  Validation on toxicity tests
5. Week  3R/(4R) principle
6. Week  Reduction and acute toxicity tests (“Fixed dose method”, “Acute toxic class method” and “Up- and down procedure”)
7. Week  Quizz
8. Week  Refinement and its methods
9. Week  Replacement and its applications (omics, microarray technologies, in silico, cell culture etc.)
10. Week  Validated and recommended for regulatory use non-animal tests -1[(Skin irritation ( EPISKIN, EpiDerm)]
11. Week  Validated and recommended for regulatory use non-animal tests -2 [Skin Sensitization (Local Lymph Node Assay LLNA -OECD 429)]
12. Week  Validated and recommended for regulatory use non-animal tests -3 [(Skin penetration (In vitro skin absorption-OECD 428)]
13. Week  Validated and recommended for regulatory use non-animal tests -4 [Skin corrosion (Corrositex OECD435 and In vitro Skin ModelTest OECD431)]
14. Week  Student presentations and discussion
15. Week  
16. Week  
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
25
 Assignment
1
25
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
 Reading Tasks
2
10
20
 Searching in Internet and Library
2
10
20
 Material Design and Implementation
0
 Report Preparing
2
10
20
 Preparing a Presentation
2
10
20
 Presentation
2
9
18
 Midterm Exam and Preperation for Midterm Exam
1
18
18
 Final Exam and Preperation for Final Exam
1
30
30
 Other (should be emphasized)
0
0
 TOTAL WORKLOAD: 
188
 TOTAL WORKLOAD / 25: 
7.52
 Course Credit (ECTS): 
7.5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X
11X
12X
13
14X
15X
 -- NAME OF LECTURER(S)
   (Prof. Bensu KARAHALİL; Prof. Ayşe Başak ENGİN)
 -- WEB SITE(S) OF LECTURER(S)
   (http://www.websitem.gazi.edu.tr/site/bensu , http://www.websitem.gazi.edu.tr/site/abengin)
 -- EMAIL(S) OF LECTURER(S)
   (bensu@gazi.edu.tr , abengin@gmail.com)