GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
THE EFFECT OF THE CHEMICAL STRUCTURE ON BIOAVAILABILITY/FKİ-3250
Course Title: THE EFFECT OF THE CHEMICAL STRUCTURE ON BIOAVAILABILITY
Credits 2 ECTS 5
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Have knowledge about the analysis of physicochemical properties of the molecule.
Have a good understanding of how physicochemical characteristics of molecule affect ADME properties.
Learns the optimal molecular structure for optimum bioavailability.
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  Drug Design and Relationship of Functional Groups to Pharmacologic Activity
2. Week  Acid–Base Properties and Predicting the Degree of Ionization of a Molecule
3. Week  Predicting Water Solubility: The Empirical Approach and Analytical/Quantitative Approach
4. Week  Stereochemistry and Biologic Activity
5. Week  Physicochemical Properties of Drug Substances and Pharmacokinetics
6. Week  Biologic Membrane and Mechanisms of Drug Absorption
7. Week  The pH-Partition Hypothesis on Drug Absorption: Ionization and pH at Absorption Site
8. Week  Dissolution: pH and Solubility of Weak Acids and Bases, Solubility and Dissolution Rate
9. Week  Crystals, Polymorphism and salt formation
10. Week  Effect of Molecular Structure on Drug Metabolism
11. Week  Drug Metabolizing Enzymes, Functional Group Metabolism and Bioavailability
12. Week  Lipophilicity and Bioavailability
13. Week  Rules of Lipinski ve Weber
14. Week  Summary of Drug Properties for Effective Bioavailability
15. Week  
16. Week  
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
50
 Assignment
1
30
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
2
20
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
2
28
 Weekly Tutorial Hours
0
0
0
 Reading Tasks
14
2
28
 Searching in Internet and Library
14
2
28
 Material Design and Implementation
0
0
0
 Report Preparing
3
5
15
 Preparing a Presentation
4
5
20
 Presentation
2
2
4
 Midterm Exam and Preperation for Midterm Exam
1
4
4
 Final Exam and Preperation for Final Exam
1
4
4
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
131
 TOTAL WORKLOAD / 25: 
5.24
 Course Credit (ECTS): 
5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7
8
9
10
11
12X
13
14X
15X
16X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Erden BANOĞLU)
 -- WEB SITE(S) OF LECTURER(S)
   (https://websitem.gazi.edu.tr/site/banoglu , http://www.tuba.gov.tr/tr/uyeler/tum-uyeler/asli-uyeler/erden-banoglu , http://www.banoglu.com)
 -- EMAIL(S) OF LECTURER(S)
   (banoglu@gazi.edu.tr)