GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION

CONCEPTUAL APPROACHES FOR THE DISCOVERY OF NEW DRUG MOLECULES/FKİ-6030

Course Title:	CONCEPTUAL APPROACHES FOR THE DISCOVERY OF NEW DRUG MOLECULES
Credits	2	ECTS	5
Course Semester	1	Type of The Course	Elective

COURSE INFORMATION

-- (CATALOG CONTENT)

-- (TEXTBOOK)

-- (SUPPLEMENTARY TEXTBOOK)

-- (PREREQUISITES AND CO-REQUISITES)

-- LANGUAGE OF INSTRUCTION

Turkish

-- COURSE OBJECTIVES

-- COURSE LEARNING OUTCOMES

Knows the modern methods and approaches used in the discovery and development of drug candidate molecules.
Learns to use ligand based technologies.
Learns to use target based technologies.
Learns to use virtual screening methods.

-- MODE OF DELIVERY

Face to Face, Direct Instruction, Visual Presentations, Student-Centered Discussions, Student Presentations

--WEEKLY SCHEDULE
1. Week	Molecular recognition principles and the role in drug discovery
2. Week	Ligand-protein interactions
3. Week	The total strength of the ligand-protein interactions
4. Week	Free energy difference in binding, entalphic and entropic components
5. Week	The freezing of overall molecular motion
6. Week	Conformational changes of ligand and protein
7. Week	Polar Interactions Involving Aromatic Ring Systems
8. Week	Hydrophobic and Van der waals interations
9. Week	Thermodynamics of optimization for improving ligand binding
10. Week	Biostructure-based drug design
11. Week	Ligand-based drug design
12. Week	Pharmacophore model development and virtual screening
13. Week	Case studies: Development of aliskiren
14. Week	Case studies: Development of neuramidinase inhibitors
15. Week
16. Week

-- TEACHING and LEARNING METHODS

-- ASSESSMENT CRITERIA

	Quantity	Total Weighting (%)
Midterm Exams	1	35
Assignment	1	35
Application	0	0
Projects	0	0
Practice	0	0
Quiz	3	30

Percent of In-term Studies		50
Percentage of Final Exam to Total Score		50

-- WORKLOAD

Activity	Total Number of Weeks	Duration (weekly hour)	Total Period Work Load
Weekly Theoretical Course Hours	14	2	28
Weekly Tutorial Hours			0
Reading Tasks	14	2	28
Searching in Internet and Library	14	1	14
Material Design and Implementation			0
Report Preparing			0
Preparing a Presentation	1	9	9
Presentation	1	1	1
Midterm Exam and Preperation for Midterm Exam	2	10	20
Final Exam and Preperation for Final Exam	2	13	26
Other (should be emphasized)	0	0	0
TOTAL WORKLOAD:			126
TOTAL WORKLOAD / 25:			5.04
Course Credit (ECTS):			5

-- COURSE'S CONTRIBUTION TO PROGRAM

NO	PROGRAM LEARNING OUTCOMES	1	2	3	4	5
1						X
2						X
3						X
4						X
5						X
6					X
7				X
8			X
9						X
10			X
11
12
13				X
14					X
15
16

-- NAME OF LECTURER(S)

(Prof. Dr. Erden BANOĞLU)

-- WEB SITE(S) OF LECTURER(S)

(http://websitem.gazi.edu.tr/site/banoglu)

-- EMAIL(S) OF LECTURER(S)

(banoglu@gazi.edu.tr)

Gazi University

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GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR