GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
Metabolism of amino acids/EBY-5030
Course Title: Metabolism of amino acids
Credits 2 ECTS 5
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
learn metabolism and regulation of amino acids
learn amino acid excretion product, ammonia and its toxicity
Know metabolic disorders and clinical importance of amino acid metabolism due to enzyme defects
Learn the special products of amino acid which are physiological importance

 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  Microbial nitrogen uptake, nitrate, nitrite, ammonia and cyanide assimilation. Amino acid sources and its uses, dietary protein intake, digestion and
2. Week  intracellular lysosomal and proteasomal protein degradation, Amino acids involved in structural proteins, essential amino acids
3. Week  Endogenous amino acid degradation, transamination and transaminases, Oxidative and non-oxidative deamination reactions and reaction mechanisms.
4. Week  Urea cycle and its regulation, enzymatic defects of urea cycle, Ammonia sources and ammonia toxicity
5. Week  Synthesis and degradation of glycine, serine, threonine amino acids, and one carbon pool, enzymatic defects and clinical significance
6. Week  Synthesis and degradation of alanine, glutamic acid, glutamine, aspartic acid, asparagine amino acids, enzymatic defects and clinical importance
7. Week  Synthesis and degradation of hydroxyproline, branched chain amino acids (valine, leucine, isoleucine), enzymatic defects and clinical importance,
8. Week  Tryptophan metabolism, neuroprotective and neurotoxic products of the tritophan-kynurenine pathway, enzymatic defects of tryptophan metabolism and cli
9. Week  synthesis and degredation pathways of phenylalanine and tyrosine, enzymatic defects in these pathways. Phenylketonuria and trozinemias, clinical evalu
10. Week  Methionine and cysteine ​​production and degradation, sulfur metabolism, enzymatic defects in these metabolic pathways, homocysteine ̴
11. Week  Lysine and arginine metabolism, enzymatic defects and clinical evaluation
12. Week  special metabolic products of amino acids: Troid hormones, DOPA, Dopamine, melanin, adrenaline and noradrenaline,
13. Week  Special metabolic products of amino acids: Seratonin, Melatonin, GABA, histamine
14. Week  Specific metabolic products of amino acids: polyamines (spermine, spermidine), nitric oxide, creatine, creatinine,
15. Week  
16. Week  
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
70
 Assignment
3
20
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
1
10
 Percent of In-term Studies  
40
 Percentage of Final Exam to Total Score  
60
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
2
28
 Weekly Tutorial Hours
0
 Reading Tasks
14
3
42
 Searching in Internet and Library
7
2
14
 Material Design and Implementation
0
 Report Preparing
3
3
9
 Preparing a Presentation
3
1
3
 Presentation
3
1
3
 Midterm Exam and Preperation for Midterm Exam
2
2
4
 Final Exam and Preperation for Final Exam
7
2
14
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
117
 TOTAL WORKLOAD / 25: 
4.68
 Course Credit (ECTS): 
5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2
3X
4X
5
6
7
8X
9X
10
11X
12X
 -- NAME OF LECTURER(S)
   ( Prof. Yeşim ÖZKAN , PhD)
 -- WEB SITE(S) OF LECTURER(S)
   (http://websitem.gazi.edu.tr/site/yesim)
 -- EMAIL(S) OF LECTURER(S)
   (yesim@gazi.edu.tr)