GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
ENDOCRINE DISRUPTORS/5791325
Course Title: ENDOCRINE DISRUPTORS
Credits 3 ECTS 7.5
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish/English
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Understand the basic chemical and ecological nature of environmental pollution processes and define major pollutant groups.
Define environmental outcomes from molecular interactions to population effects; understand bioaccumulation.
Discuss mechanisms of action of endocrine system active/disruptor compouds’ (EDCs) in the laboratory and the field together with biomarker strategies.
Understand the national and international level risks posed by EDCs and other pollutants of concern when they are present together in so small amounts
Discuss national and international legislation on EDC activity determination, assessment and risk characterization methodologies.

 -- MODE OF DELIVERY
  Face to face
 --WEEKLY SCHEDULE
1. Week  Introduction to endocrinology and environmental toxicology.
2. Week  Environmental Endocrinology Theory. History, Silent Spring and Rachel Carson, WHO definition of EDCs.
3. Week  Routes of entry and exposure into the ecosystem. Exposure sources from contaminated groundwater, incineration facilities and waste landfill.
4. Week  Basic toxicological principles: Dose-response relationships, absorption, distribution, storage, biotransformation and excretion of toxicants.
5. Week  Target organ toxicity and teratogenesis, mutagenesis and carcinogenesis of toxicants. Chemodynamics, transport and outcome of environmental pollutants
6. Week  Major EDC groups and examples. Reasons for EDC exposure concern. Risk assessment.
7. Week   Midterm Exam
8. Week  Mechanisms of action of EDCs in animals and humans. Receptors and mechanisms of action. Discussion and comparison of cellular, tissue, organ and popul
9. Week  Bioaccumulation and biomarkers used in the laboratory and field for measurement of ED activity. Personal care products, pharmaceuticals and engineered
10. Week  Standardized testing/guidelines used for determining reproductive and endocrine effects of EDCs; ethical issues and regulatory action, topics of discu
11. Week  Standardized testing/guidelines used for determining reproductive and endocrine effects of EDCs; ethical issues and regulatory action, topics of discu
12. Week  Complexity and difficulties of risk assessment and risk management.
13. Week  Wildlife effects of environmental EDCs. Case studies/samples will be presented.
14. Week  Health effects of EDCs on reproduction, thyroid function and fetus. Representative examples will be presented with literature survey
15. Week  Representative examples will be presented with literature survey
16. Week  -
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
20
 Assignment
1
10
 Application
0
0
 Projects
1
20
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
 Reading Tasks
10
2
20
 Searching in Internet and Library
10
2
20
 Material Design and Implementation
0
 Report Preparing
8
2
16
 Preparing a Presentation
8
2
16
 Presentation
8
2
16
 Midterm Exam and Preperation for Midterm Exam
12
1
12
 Final Exam and Preperation for Final Exam
12
3
36
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
178
 TOTAL WORKLOAD / 25: 
7.12
 Course Credit (ECTS): 
7.5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X
11X
12X
13X
14X
15X
16X
17X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Figen Ünlü Erkoç)
 -- WEB SITE(S) OF LECTURER(S)
   (http://websitem.gazi.edu.tr/erkoc , http://www.websitem.gazi.edu.tr/site/erkoc/files)
 -- EMAIL(S) OF LECTURER(S)
   (erkoc@gazi.edu.tr)