GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
TRANSCRIPTOME/TBG-2060
Course Title: TRANSCRIPTOME
Credits 3 ECTS 9
Semester 2 Compulsory/Elective Elective
COURSE INFO
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- NAME OF LECTURER(S)
  Prof. Dr. Ece Konaç
 -- WEB SITE(S) OF LECTURER(S)
   http://websitem.gazi.edu.tr/site/ecem
 -- EMAIL(S) OF LECTURER(S)
  ecem@gazi.edu.tr; ecemercanoglu@yahoo.com
 -- LEARNING OUTCOMES OF THE COURSE UNIT
To learn the biological functions of genes and their products on molecular level
Learns the DNA structure
Learns the DNA replication
Learns the gene transcription
Learns the gene translation
Gets acquainted with molecular biology focusing on gene transcription and protein-protein interactions
Learns the regulatory mechanisms of transcription
Learns the regulatory mechanisms of translation
Learns the epigenetic and epigenome
Learns the genome analysis and systems biology
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face.
 -- PREREQUISITES AND CO-REQUISITES
  There is no prerequisite or co-requisite for this course.
 -- RECOMMENDED OPTIONAL PROGRAMME COMPONENTS
  There is no recommended optional programme component for this course.
 --COURSE CONTENT
1. Week  Overview of central dogma
2. Week  Transcriptional regulation in eukaryotes
3. Week   What is epigenetic/epigenomics?
4. Week  Epigenetic molecular mechanisms
5. Week  Epigenetic gene regulation
6. Week  Functional and positional cloning
7. Week  Functional genomics
8. Week  Gene expressiom analysis methods
9. Week  Mutation analysis, microarray, western blotting
10. Week  Regulatory RNAs
11. Week  Proteomics
12. Week  Metabolomics
13. Week  Genome analysis and systems biology
14. Week  Up- to-date approach
15. Week   Up- to-date approach -2
16. Week  Final Exam
 -- RECOMMENDED OR REQUIRED READING
  Molecular Biology of the Gene, 6th Edition, Watson, 2010. StemBook Cambridge (MA): Harvard Stem Cell Institute; 2008. Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Holland-Frei Cancer Medicine. 6th edition. Kufe DW, Pollock RE, Weichselbaum RR, et al., editors., 2003
 -- PLANNED LEARNING ACTIVITIES AND TEACHING METHODS
  Lecture, Question & Answer
 -- WORK PLACEMENT(S)
  NA
 -- ASSESSMENT METHODS AND CRITERIA
 
Quantity
Percentage
 Mid-terms
1
40
 Assignment
0
0
 Exercises
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Contribution of In-term Studies to Overall Grade  
40
 Contribution of Final Examination to Overall Grade  
60
 -- WORKLOAD
 Efficiency  Total Week Count  Weekly Duration (in hour)  Total Workload in Semester
 Theoretical Study Hours of Course Per Week
16
3
48
 Practising Hours of Course Per Week
0
 Reading
15
3
45
 Searching in Internet and Library
15
3
45
 Designing and Applying Materials
0
 Preparing Reports
0
 Preparing Presentation
0
 Presentation
0
 Mid-Term and Studying for Mid-Term
0
 Final and Studying for Final
9
4
36
 Other
14
4
56
 TOTAL WORKLOAD: 
230
 TOTAL WORKLOAD / 25: 
9.2
 ECTS: 
9
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1- Understanding of basic concepts in genetics ,application of genetic information in diagnosis and monitoring the course of human diseases,application of genetic technologies in medicine,advanced molecular genetics,cellular biology,molecular biology of human neoplastic diseases.X
2Learning structures of cell membranes and organelles in detail at the molecular level.X
3Learning basic rules of patterns of inheritance and pedigree analysis.X
4Knowing chemical and physical properties of DNA, RNA and proteins.X
5Becoming familiar with new instruments and technologies that are required to do an experimental research in the cell and molecular biology labs.X
6Learns the basic molecules which are responsible for the storage and duplication of genetic information and its transfer into proteins .X
7Gets acquainted with molecular biology focusing on gene transcription and protein-protein interactionsX
8Acquaring skills of DNA and RNA isolation, quantitating DNA or RNA, PCR, electrophoresis, RT-PCR, cell culture.X
9Understanding the roles of genetic and epigenetic mechanisms observed in genes in the process of evolution and transmit of hereditary features and disorders from one generation to another.X
10Learns the meaning of genetic code and its role in the relationship between the structure and function of organisms.X