GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
MUTATIONS/TBG-2070
Course Title: MUTATIONS
Credits 3 ECTS 9
Semester 2 Compulsory/Elective Elective
COURSE INFO
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- NAME OF LECTURER(S)
  Prof. Dr. Ece KONAC, Assoc.Prof. Dr. Hacer Ilke ONEN, Assoc.Prof. Dr. Atiye Seda YAR SAGLAM
 -- WEB SITE(S) OF LECTURER(S)
  http://www.websitem.gazi.edu.tr/site/ecem, http://www.websitem.gazi.edu.tr/site/hionen, http://www.websitem.gazi.edu.tr/site/sedayar
 -- EMAIL(S) OF LECTURER(S)
   ecem@gazi.edu.tr, hionen@gazi.edu.tr, atiyeseda@yahoo.com
 -- LEARNING OUTCOMES OF THE COURSE UNIT
To be able to explain the relationship between mutation and genetic disease
To be able to classify mutations according to their reasons
To be able to classify mutations according to results
To be able to classify mutations according to their phenotypic effects
To be able to classify chromosomal mutations
To be able to explain genetic diseases resulting from chromosomal mutations
To be able to classify mutagens
To be able to explain the contribution of mutations to evolution
To be able to explain mutations caused by transposons
To be able to explain the relationship between epigenetic mutation and genetic diseases
 -- MODE OF DELIVERY
  The mode of delivery of this course is face to face
 -- PREREQUISITES AND CO-REQUISITES
  There is no prerequisite or co-requisite for this course.
 -- RECOMMENDED OPTIONAL PROGRAMME COMPONENTS
  There is no recommended optional programme component for this course.
 --COURSE CONTENT
1. Week  The relationship between mutation and genetic disease
2. Week  Classification of mutations according to their causes
3. Week  Classification of mutations according to results
4. Week  Classification of mutations according to phenotypic effects
5. Week  The concept of mutagen and classification of mutagens
6. Week  Evaluation of teratogens and their effects
7. Week  Chromosomal mutations
8. Week  Presentation assignment
9. Week  Midterm
10. Week  Genetic diseases resulting from chromosomal mutations
11. Week  Contribution of mutations to evolution
12. Week  The concept of transposon and the classification of transposons
13. Week  Diseases caused by transposons
14. Week  DNA repair mechanisms
15. Week  Epigenetic mutations and their relationship with genetic diseases
16. Week  Final exam
 -- RECOMMENDED OR REQUIRED READING
  Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Keith Roberts, Peter Walter. Molecular Biology of the Cell (Ed.6th), Garland Science, USA, 2014. Tom Strachan, Andrew Read, Human Molecular Genetics (Ed.4th), 2010.
 -- PLANNED LEARNING ACTIVITIES AND TEACHING METHODS
  Lecture, Question & Answer
 -- WORK PLACEMENT(S)
  N/A
 -- ASSESSMENT METHODS AND CRITERIA
 
Quantity
Percentage
 Mid-terms
1
30
 Assignment
1
10
 Exercises
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Contribution of In-term Studies to Overall Grade  
40
 Contribution of Final Examination to Overall Grade  
60
 -- WORKLOAD
 Efficiency  Total Week Count  Weekly Duration (in hour)  Total Workload in Semester
 Theoretical Study Hours of Course Per Week
13
3
39
 Practising Hours of Course Per Week
0
0
0
 Reading
13
4
52
 Searching in Internet and Library
13
3
39
 Designing and Applying Materials
0
0
0
 Preparing Reports
0
0
0
 Preparing Presentation
7
4
28
 Presentation
1
1
1
 Mid-Term and Studying for Mid-Term
8
5
40
 Final and Studying for Final
6
5
30
 Other
0
 TOTAL WORKLOAD: 
229
 TOTAL WORKLOAD / 25: 
9.16
 ECTS: 
9
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1- Understanding of basic concepts in genetics ,application of genetic information in diagnosis and monitoring the course of human diseases,application of genetic technologies in medicine,advanced molecular genetics,cellular biology,molecular biology of human neoplastic diseases.X
2Learning structures of cell membranes and organelles in detail at the molecular level.
3Learning basic rules of patterns of inheritance and pedigree analysis.
4Knowing chemical and physical properties of DNA, RNA and proteins.X
5Becoming familiar with new instruments and technologies that are required to do an experimental research in the cell and molecular biology labs.
6Learns the basic molecules which are responsible for the storage and duplication of genetic information and its transfer into proteins .X
7Gets acquainted with molecular biology focusing on gene transcription and protein-protein interactionsX
8Acquaring skills of DNA and RNA isolation, quantitating DNA or RNA, PCR, electrophoresis, RT-PCR, cell culture.
9Understanding the roles of genetic and epigenetic mechanisms observed in genes in the process of evolution and transmit of hereditary features and disorders from one generation to another.X
10Learns the meaning of genetic code and its role in the relationship between the structure and function of organisms.X