GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
DRUG RECEPTOR INTERACTIONS AND SIGNAL TRANSDUCTION MECHANISMS/FRL-2030
Course Title: DRUG RECEPTOR INTERACTIONS AND SIGNAL TRANSDUCTION MECHANISMS
Credits 3 ECTS 5
Course Semester 1 Type of The Course Compulsory
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
To define principles, elements and philosophy of advanced cell signalling mechanisms.
To define the reactive oxygen species, derivatives and metabolites and their functions as a signalling molecules.
To define the cellular oxidative and reductive stressors, and should discuss the variety of cellular stress responses and redox homeostas
To define Advenced Lipoxidation and Advenced Glycation End Products, and should discuss their roles in diseases pathogenesis.
To explain endoplasmic reticulum stress and mithocondrial stress and the different roles of antioxidants.
To explain the consequences and mechanisms of cellular Senescence.
To explain and discuss the apoptotic pathways, the results of polyphagia and their inhibitors.
To define and discuss key cancer cell signal transduction pathways as therapeutic targets.
To explain Signal Transduction and Signal Modulation by Cell Adhesion Receptors.
To discuss the changes in cellular signal transduction mechanisms in Diabetes and Alzheimer's.
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  What is advanced cell signalling?
2. Week  Complex signal transduction pathway.
3. Week  Redox control of cellular signal transduction.
4. Week  Reactive oxygen species as a signalling molecules.
5. Week  Reactive oxygen metabolites as a signalling molecules.
6. Week  Oxidative and Reductive Stressors and Cellular Responses.
7. Week  What is the role of glutathione in cell signalling?
8. Week  Advenced Lipoxidation and Advenced Glycoxidation End Products and Disease States.
9. Week  Signalling in endoplasmic reticulum stress and mithocondrial stress.
10. Week  Signal transduction in cellular senescence.
11. Week  Apoptosis and Signal Transduction.
12. Week  Polyphagia and Signal Transduction.
13. Week  Signal Transduction and Cancer.
14. Week  Signal Transduction and Autoimmune diseases.
15. Week  N/A
16. Week  N/A
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
20
 Assignment
1
10
 Application
0
0
 Projects
1
5
 Practice
0
0
 Quiz
1
5
 Percent of In-term Studies  
40
 Percentage of Final Exam to Total Score  
60
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
 Reading Tasks
14
3
42
 Searching in Internet and Library
0
 Material Design and Implementation
0
 Report Preparing
0
 Preparing a Presentation
6
2
12
 Presentation
6
1
6
 Midterm Exam and Preperation for Midterm Exam
7
2
14
 Final Exam and Preperation for Final Exam
7
1
7
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
123
 TOTAL WORKLOAD / 25: 
4.92
 Course Credit (ECTS): 
5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1Can obtain current pharmacological knowledge in a systematically approach.X
2Contribute to science by expanding the boundaries of knowledge in the field of pharmacology.X
3Define the scientific research methods of the discipline of pharmacology. Plan, conduct and analyze a scientific research and write and publish the data.X
4Can access scientific data and interpret data critically.X
5Prepare a scientific presentation and present it properly.X
6Have the adequate knowledge and skills of research techniques to be able to take part in experiments conducted with laboratory animals.X
7Adopts the ethical and other responsibilities imposed by the discipline of pharmacology.X
8Should be able to read, analyze and evaluate the publications in the field of pharmacology published in a foreign language at international levels.X
9Accepts the value of evidence-based scientific thinking and critical thinking approach in the field of pharmacology and its applications, and attaches importance to lifelong learning.X
10Be able to evaluate a scientific research project within the discipline of pharmacology from an ethical.X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Çimen KARASU and other faculty members in our department)
 -- WEB SITE(S) OF LECTURER(S)
   (www.cimenkarasu.com)
 -- EMAIL(S) OF LECTURER(S)
   (Cimen Karasu Zafer Güney Canan Uluoglu , sevil ilhan , Süreyya BARUN , Ergin Dilekoz , Gokce Ozturk )