GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
MECHANISMS OF CELLULAR TOXICITY/FTO-1090
Course Title: MECHANISMS OF CELLULAR TOXICITY
Credits 3 ECTS 7.5
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
To learn general principles in toxicity
To gain information about damage in cell organalles and xenobiotic samples
To gain information about cell homeostasis and xenobiotics that interrupt cellular homeostasis
 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  Introduction to general toxicity mechanisms
2. Week  Interaction of xenobiotics with cellular components
3. Week  Effects of xenobiotics on reseptors
4. Week  Effects of xenobiotics on certain enzymes
5. Week  Effects of xenobiotics on certain proteins
6. Week  Effects of xenobiotics on intra/inter cellular signal pathways
7. Week  Mid-term exam
8. Week  Effects of xenobiotics on Calcium homeostasis
9. Week  Effects of xenobiotics on membrane functions
10. Week  Effects of xenobiotics on cellular energy production
11. Week  Apoptosis and necrosis mechanisms related with exposure to toxicans
12. Week  Oxidative damage and mechanisms due to xenobiotic exposure
13. Week  Effects of xenobiotics on antioxidant defense systems
14. Week  Methods for determination of toxic effects in cellular level 1
15. Week  Methods for determination of toxic effects in cellular level 2
16. Week  Final exam and presentation
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
30
 Assignment
2
20
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
13
3
39
 Weekly Tutorial Hours
0
0
0
 Reading Tasks
10
5
50
 Searching in Internet and Library
3
6
18
 Material Design and Implementation
0
0
0
 Report Preparing
0
0
0
 Preparing a Presentation
2
15
30
 Presentation
2
4
8
 Midterm Exam and Preperation for Midterm Exam
1
21
21
 Final Exam and Preperation for Final Exam
1
21
21
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
187
 TOTAL WORKLOAD / 25: 
7.48
 Course Credit (ECTS): 
7.5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1The ability to understand the principles of toxicologyX
2The ability to design and conduct experiments, to evaluate and interpret critically toxicity data.X
3Effectively use acquired laboratory skills in toxicological researchX
4The ability to use necessary techniques and modern analysis tools for toxicological analysis practice
5Undertake complex toxicology data analysis, the ability to analyze, synthesize and evaluate new ideas
6The ability to work effectively as an individual, in teams, and in multidisciplinaryX
7Display excellence and innovation in problem-solving skills, demonstrate a sophisticated level of interpretation and the ability to communicate both orally and in writing at a high level of proficiencyX
8The ability to evaluate and to apply human health risks caused by drugs and other chemicals. Perform complicated chemical risk assessments.X
9The ability of monitoring, searching and evaluating the advers drug effectsX
10To know the principles of first aid and treatment of poisoning and the ability to make the effective guidance
11Be able to describe thoroughly the chemical concentration/dose to the observed toxicity effects and to understand the mode of action of the chemicals or its metabolites in living organismsX
12To understand the mechanisms of the production of the free radicals, oxidative stress and the relation of the radicals to the xenobiotic metabolism and their toxicological significanceX
13Gaining knowledge on the immune system, effects of the xenobiotics on the immune system, pathological alterations of the biological system due to these alterations.X
14To achieve current knowledge and awareness with regards to the national and international regulation of chemical, physical and biological agents and use of toxicology data in regulation approach.X
15To learn application and evaluation of toxic effects of chemicals by in vivo and in vitro test systems.X
 -- NAME OF LECTURER(S)
   (Assoc.Prof.Ela Kadıoğlu)
 -- WEB SITE(S) OF LECTURER(S)
   ()
 -- EMAIL(S) OF LECTURER(S)
   (ela@gazi.edu.tr)