GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
TOXICOKINETICS/FTO-2070
Course Title: TOXICOKINETICS
Credits 3 ECTS 7.5
Course Semester 1 Type of The Course Compulsory
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
To learn ADME of xenobiotics in body

 -- MODE OF DELIVERY
  The mode of delivery of this course is Face to face
 --WEEKLY SCHEDULE
1. Week  Routes of exposure and transport of drugs across biological membranes
2. Week  Structure and composition of biological membranes
3. Week  Transport mechanisms
4. Week  Drug distribution
5. Week  Phase I biotransformation reactions, their mechanisms and drug examples
6. Week  Mixed function oxidizes and P450 catalytic cycle
7. Week  Homework and midterm exam
8. Week  Mixed function and non-microsomal oxidation reactions
9. Week  Bioactivation
10. Week  Phase II biotransformation reactions, their mechanism and drug examples
11. Week  Elimination pathways
12. Week  Roles of physiological, chemical and environmental factors influencing metabolism
13. Week  Enzyme induction and its clinical significance
14. Week  Enzyme inhibition, induction and their clinical significance
15. Week  
16. Week  
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
25
 Assignment
1
25
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
0
0
 Reading Tasks
10
8
80
 Searching in Internet and Library
7
3
21
 Material Design and Implementation
0
0
0
 Report Preparing
4
3
12
 Preparing a Presentation
4
3
12
 Presentation
4
2
8
 Midterm Exam and Preperation for Midterm Exam
1
4
4
 Final Exam and Preperation for Final Exam
1
8
8
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
187
 TOTAL WORKLOAD / 25: 
7.48
 Course Credit (ECTS): 
7.5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1The ability to understand the principles of toxicologyX
2The ability to design and conduct experiments, to evaluate and interpret critically toxicity data.X
3Effectively use acquired laboratory skills in toxicological research
4The ability to use necessary techniques and modern analysis tools for toxicological analysis practice
5Undertake complex toxicology data analysis, the ability to analyze, synthesize and evaluate new ideasX
6The ability to work effectively as an individual, in teams, and in multidisciplinaryX
7Display excellence and innovation in problem-solving skills, demonstrate a sophisticated level of interpretation and the ability to communicate both orally and in writing at a high level of proficiencyX
8The ability to evaluate and to apply human health risks caused by drugs and other chemicals. Perform complicated chemical risk assessments.X
9The ability of monitoring, searching and evaluating the advers drug effectsX
10To know the principles of first aid and treatment of poisoning and the ability to make the effective guidanceX
11Be able to describe thoroughly the chemical concentration/dose to the observed toxicity effects and to understand the mode of action of the chemicals or its metabolites in living organismsX
12To understand the mechanisms of the production of the free radicals, oxidative stress and the relation of the radicals to the xenobiotic metabolism and their toxicological significanceX
13Gaining knowledge on the immune system, effects of the xenobiotics on the immune system, pathological alterations of the biological system due to these alterations.X
14To achieve current knowledge and awareness with regards to the national and international regulation of chemical, physical and biological agents and use of toxicology data in regulation approach.X
15To learn application and evaluation of toxic effects of chemicals by in vivo and in vitro test systems.X
 -- NAME OF LECTURER(S)
   (Prof.Dr. İsmet ÇOK , Prof.Dr.Gonca Çakmak DEMİRCİGİL)
 -- WEB SITE(S) OF LECTURER(S)
   (websitem.gazi.edu.tr/site/ismetc)
 -- EMAIL(S) OF LECTURER(S)
   (ismetc@gazi.edu.tr , goncacd@gmail.com)