GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
DRUG DESIGN/FKİ-1050
Course Title: DRUG DESIGN
Credits 2 ECTS 6
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Be able to define the general principles of drug design.
Be able to describe the process of drug discovery and development.
Have gained a basic knowledge of computational methods used in drug design.
Be able to determine the relationship between chemical structure and activity of the drug.
Have gained a basic knowledge of lead optimisation methods and processes.

 -- MODE OF DELIVERY
  The mode of delivery of this course is face to face
 --WEEKLY SCHEDULE
1. Week  The historical development of drug design and discovery
2. Week  Drug targets
3. Week  Selectivity of drug aciton and receptors
4. Week  Approaches for identifying lead compound
5. Week  Computer-aided drug design (CADD)
6. Week  Successful applications of drug design: Captopril
7. Week  Midterm exam
8. Week  Successful applications of drug design: Cimetidine
9. Week  Successful applications of drug design: Dorzolamide
10. Week  Successful applications of drug design: Imatinib
11. Week  Successful applications of drug design: Zanamivir
12. Week  CADD success stories: RAF/VEGFR2 inhibitors
13. Week  CADD success stories: mGluR5 receptor negative modulator
14. Week  CADD success stories: SIRT inhibitors
15. Week  CADD success stories: Pim-1 kinase inhibitors and presentations
16. Week  Final exam
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
60
 Assignment
1
40
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
2
28
 Weekly Tutorial Hours
0
0
0
 Reading Tasks
10
2
20
 Searching in Internet and Library
5
3
15
 Material Design and Implementation
0
0
0
 Report Preparing
3
5
15
 Preparing a Presentation
4
7
28
 Presentation
1
2
2
 Midterm Exam and Preperation for Midterm Exam
2
5
10
 Final Exam and Preperation for Final Exam
3
7
21
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
139
 TOTAL WORKLOAD / 25: 
5.56
 Course Credit (ECTS): 
6
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1Applies current knowledge in the field of Pharmaceutical Chemistry with the related field.X
2Comprehends the interdisciplinary interaction related to the field of Pharmaceutical Chemistry and interprets the information to integrate and create new information.X
3Reaches the information about the research topic from national and international resources, compiles and interprets them.X
4Prepares scientific reports of his/her research activities.X
5Uses laboratory equipment including computer which is required during experimental research.X
6Presents the results of the work at national or international meetings organized in the field of expertise.
7Knows the importance of ethical principles and ethical rules for individual and society, behaves ethically.X
8Applies advanced organic chemistry knowledge and chemical synthesis procedures.
9Performs experiments using separation and purification methods.
10Elucidates molecular structures using spectral analysis.
11Evaluates the behavior of the drug in biological systems and proposes a new chemical molecule for drug design.X
12Has the knowledge about qualitative and quantitative analysis methods of drugs and applies them.X
13Knows advanced organic chemistry, behavior of drugs in biological systems, qualitative-quantitative and spectral structure analysis methods of drugs, including separation and purification methods.
 -- NAME OF LECTURER(S)
   (Assoc. Prof. Gokcen EREN)
 -- WEB SITE(S) OF LECTURER(S)
   (https://abs.gazi.edu.tr/gokcene)
 -- EMAIL(S) OF LECTURER(S)
   (gokcene@gazi.edu.tr)