GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
MOLECULAR BIOISOSTERISM/FKİ-1220
Course Title: MOLECULAR BIOISOSTERISM
Credits 2 ECTS 6
Course Semester 1 Type of The Course Compulsory
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Understands the bioisosterism concept
Understands the role of the bioisosterism approaches in drug discovery
Relates the bioisosteric replacements with pharmacological outcomes
 -- MODE OF DELIVERY
  Direct Instruction, Visual Presentations, Student-Centered Discussions, Student Presentations
 --WEEKLY SCHEDULE
1. Week  What is bioisoster? The role of bioisosters in drug design. Classical and non-classical bioisosters.
2. Week  The use of bioisosters to increase metabolic stability and examples
3. Week  Effects of bioisosters on pKa
4. Week  Effects of bioisosters on molecular conformation
5. Week  Tactical utilisation of bioisosters in drug development
6. Week  Utilisation of flour atom to improve drug-like properties
7. Week  Analysis of bioisosterism approach in analog design
8. Week  Modification of core structures
9. Week  Carboxylic acid bioisosters and examples
10. Week  Urea and thiourea bioisosters and examples
11. Week  Phenol and cathecol bioisosterism and examples
12. Week  Pyridine, imidazo[1,2-a]pyridine, pyridazine bioisosterism and examples
13. Week  Structure-based bioisostersim approach: Protease inhibitors, angiotensin converting-enzyme inhibitors
14. Week  Bioisosterism and modification of chemical space
15. Week  
16. Week  
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
50
 Assignment
1
30
 Application
0
0
 Projects
0
0
 Practice
0
0
 Quiz
3
20
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
2
28
 Weekly Tutorial Hours
0
0
0
 Reading Tasks
8
2
16
 Searching in Internet and Library
12
2
24
 Material Design and Implementation
0
0
0
 Report Preparing
4
3
12
 Preparing a Presentation
4
4
16
 Presentation
1
1
1
 Midterm Exam and Preperation for Midterm Exam
4
7
28
 Final Exam and Preperation for Final Exam
5
5
25
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
150
 TOTAL WORKLOAD / 25: 
6
 Course Credit (ECTS): 
6
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1Applies current knowledge in the field of Pharmaceutical Chemistry with the related field.X
2Comprehends the interdisciplinary interaction related to the field of Pharmaceutical Chemistry and interprets the information to integrate and create new information.X
3Reaches the information about the research topic from national and international resources, compiles and interprets them.X
4Prepares scientific reports of his/her research activities.X
5Uses laboratory equipment including computer which is required during experimental research.
6Presents the results of the work at national or international meetings organized in the field of expertise.X
7Knows the importance of ethical principles and ethical rules for individual and society, behaves ethically.X
8Applies advanced organic chemistry knowledge and chemical synthesis procedures.
9Performs experiments using separation and purification methods.
10Elucidates molecular structures using spectral analysis.
11Evaluates the behavior of the drug in biological systems and proposes a new chemical molecule for drug design.X
12Has the knowledge about qualitative and quantitative analysis methods of drugs and applies them.
13Knows advanced organic chemistry, behavior of drugs in biological systems, qualitative-quantitative and spectral structure analysis methods of drugs, including separation and purification methods.X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Erden Banoğlu)
 -- WEB SITE(S) OF LECTURER(S)
   (http://www.websitem.gazi.edu.tr/site/banoglu)
 -- EMAIL(S) OF LECTURER(S)
   (banoglu@gazi.edu.tr)