GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION

Free Radicals in Biology/EBY-1070

COURSE INFORMATION

-- (CATALOG CONTENT)

-- (TEXTBOOK)

-- (SUPPLEMENTARY TEXTBOOK)

-- (PREREQUISITES AND CO-REQUISITES)

-- LANGUAGE OF INSTRUCTION

Turkish

-- COURSE OBJECTIVES

-- COURSE LEARNING OUTCOMES

Learning the oxygen toxicity, sources and targets of reactive oxygen and nitrogen species, free radical-related diseases.

-- MODE OF DELIVERY

The mode of delivery of this course is face to face.

--WEEKLY SCHEDULE
1. Week	Oxygen toxicity in aerobes, causes the toxic effects of oxygen and affecting factors
2. Week	Reactive oxygen species; singlet oxygen, hydroxyl radical, superoxide radical, hydrogen peroxide, ozone
3. Week	Reactive nitrogen species; nitrates, nitrites and nitric oxide
4. Week	Cellular sources of free radicals, free radicals generating by enzymatic chemical reactions
5. Week	Other sources of free radicals, ionizing radiation, some drugs, air pollutants
6. Week	Specific biological targets:DNA.
7. Week	Specific biological targets: Proteins and lipids
8. Week	Damage to membranes, mechanism and products of lipid peroxidation
9. Week	Mechanism of damage to cellular targets by oxidative stress
10. Week	Detection and measurement of oxidative stress markers in biological sistems
11. Week	Reactive oxygen species/reactive nitrogen species and carcinogenesis, changes in antioxidant defences in cancer
12. Week	The role of reactive oxygen species/reactive nitrogen species in atherosclerosis
13. Week	Consequences of hypoxia, reoxygenation injury, relationship between free radicals and ischemia-reperfusion injury,
14. Week	Other diseases associated with free radicals, mechanisms of toxicity
15. Week
16. Week

-- TEACHING and LEARNING METHODS

-- ASSESSMENT CRITERIA

	Quantity	Total Weighting (%)
Midterm Exams	1	80
Assignment	1	20
Application	0	0
Projects	0	0
Practice	0	0
Quiz	0	0

Percent of In-term Studies		40
Percentage of Final Exam to Total Score		60

-- WORKLOAD

Activity	Total Number of Weeks	Duration (weekly hour)	Total Period Work Load
Weekly Theoretical Course Hours	14	2	28
Weekly Tutorial Hours			0
Reading Tasks	3	6	18
Searching in Internet and Library	3	6	18
Material Design and Implementation			0
Report Preparing	1	3	3
Preparing a Presentation	3	6	18
Presentation	3	6	18
Midterm Exam and Preperation for Midterm Exam	1	6	6
Final Exam and Preperation for Final Exam	1	8	8
Other (should be emphasized)			0
TOTAL WORKLOAD:			117
TOTAL WORKLOAD / 25:			4.68
Course Credit (ECTS):			5

-- COURSE'S CONTRIBUTION TO PROGRAM

NO	PROGRAM LEARNING OUTCOMES	1	2	3	4	5
1	Explains the basic biochemical reactions, molecular mechanisms from cell to organism, associates them with each other, discusses and interprets the structure-function relationship		X
2	Define the basic concepts and issues related to biochemistry and relate this knowledge to other disciplines.		X
3	Applies the basic experimental techniques and protocols safely in the laboratory.
4	Design original scientific research, interpret experimental data		X
5	Presents his / her work through written, oral and visual presentations. Creates new experimental protocols and evaluates statistical data.		X
6	Comprehends the principles, quality control and reliability of analytical devices used in both routine clinical laboratories and research laboratories.
7	Interprets the normal functioning mechanism of the organism on a biochemical basis.			X
8	Applies the methods used in routine biochemistry laboratories and interprets the results clinically.
9	Understands the importance of biochemistry discipline for public health and share information with the public. Carry out scientific studies with ethical responsibilty		X
10	Applies working principles in accordance with the disciplinary and interdisciplinary professions.
11	Follow the scientific literature and draw conclusions, associate them with their researches and use them in their researches.			X

-- NAME OF LECTURER(S)

(Prof.Meral TORUN)

-- WEB SITE(S) OF LECTURER(S)

(http://websitem.gazi.edu.tr/site/mtorun)

-- EMAIL(S) OF LECTURER(S)

(mtorun@gazi.edu.tr)

Gazi University