GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
ENDOCRINE DISRUPTORS/5791325
Course Title: ENDOCRINE DISRUPTORS
Credits 3 ECTS 7.5
Course Semester 1 Type of The Course Elective
COURSE INFORMATION
 -- (CATALOG CONTENT)
 -- (TEXTBOOK)
 -- (SUPPLEMENTARY TEXTBOOK)
 -- (PREREQUISITES AND CO-REQUISITES)
 -- LANGUAGE OF INSTRUCTION
  Turkish/English
 -- COURSE OBJECTIVES
 -- COURSE LEARNING OUTCOMES
Understand the basic chemical and ecological nature of environmental pollution processes and define major pollutant groups.
Define environmental outcomes from molecular interactions to population effects; understand bioaccumulation.
Discuss mechanisms of action of endocrine system active/disruptor compouds’ (EDCs) in the laboratory and the field together with biomarker strategies.
Understand the national and international level risks posed by EDCs and other pollutants of concern when they are present together in so small amounts
Discuss national and international legislation on EDC activity determination, assessment and risk characterization methodologies.

 -- MODE OF DELIVERY
  Face to face
 --WEEKLY SCHEDULE
1. Week  Introduction to endocrinology and environmental toxicology.
2. Week  Environmental Endocrinology Theory. History, Silent Spring and Rachel Carson, WHO definition of EDCs.
3. Week  Routes of entry and exposure into the ecosystem. Exposure sources from contaminated groundwater, incineration facilities and waste landfill.
4. Week  Basic toxicological principles: Dose-response relationships, absorption, distribution, storage, biotransformation and excretion of toxicants.
5. Week  Target organ toxicity and teratogenesis, mutagenesis and carcinogenesis of toxicants. Chemodynamics, transport and outcome of environmental pollutants
6. Week  Major EDC groups and examples. Reasons for EDC exposure concern. Risk assessment.
7. Week   Midterm Exam
8. Week  Mechanisms of action of EDCs in animals and humans. Receptors and mechanisms of action. Discussion and comparison of cellular, tissue, organ and popul
9. Week  Bioaccumulation and biomarkers used in the laboratory and field for measurement of ED activity. Personal care products, pharmaceuticals and engineered
10. Week  Standardized testing/guidelines used for determining reproductive and endocrine effects of EDCs; ethical issues and regulatory action, topics of discu
11. Week  Standardized testing/guidelines used for determining reproductive and endocrine effects of EDCs; ethical issues and regulatory action, topics of discu
12. Week  Complexity and difficulties of risk assessment and risk management.
13. Week  Wildlife effects of environmental EDCs. Case studies/samples will be presented.
14. Week  Health effects of EDCs on reproduction, thyroid function and fetus. Representative examples will be presented with literature survey
15. Week  Representative examples will be presented with literature survey
16. Week  -
 -- TEACHING and LEARNING METHODS
 -- ASSESSMENT CRITERIA
 
Quantity
Total Weighting (%)
 Midterm Exams
1
20
 Assignment
1
10
 Application
0
0
 Projects
1
20
 Practice
0
0
 Quiz
0
0
 Percent of In-term Studies  
50
 Percentage of Final Exam to Total Score  
50
 -- WORKLOAD
 Activity  Total Number of Weeks  Duration (weekly hour)  Total Period Work Load
 Weekly Theoretical Course Hours
14
3
42
 Weekly Tutorial Hours
0
 Reading Tasks
10
2
20
 Searching in Internet and Library
10
2
20
 Material Design and Implementation
0
 Report Preparing
8
2
16
 Preparing a Presentation
8
2
16
 Presentation
8
2
16
 Midterm Exam and Preperation for Midterm Exam
12
1
12
 Final Exam and Preperation for Final Exam
12
3
36
 Other (should be emphasized)
0
 TOTAL WORKLOAD: 
178
 TOTAL WORKLOAD / 25: 
7.12
 Course Credit (ECTS): 
7.5
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1Using the data which limited or missing information to complete the scientific methods,skills in various disciplines integration informations. Competence to work in an independent and taking responsibility. Learning Competency. Field Specific Competency. Communication and Social Competence. Ability to transfer processes and results of studies a clear written or verbal.X
2Ability to identify, formulate, and solve complex engineering problems; ability to select and apply proper analysis and modeling methods for this purposeX
3Ability to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the desired result; ability to apply modern design methods for this purpose. (Realistic constraints and conditions may include factors such as economic and environmental issues, sustainability, manufacturability, ethics, health, safety issues, and social and political issues, according to the nature of the design.)X
4Ability to devise, select, and use modern techniques and tools needed for scientific practice; ability to employ information technologies effectively.X
5Recognition of the need for lifelong learning; ability to access information, to follow developments in science and technology, and to continue to educate him/herself.X
6Ability to combine the knowledge in different disciplines efficiently and ability to solve the complex problemsX
77. Ability to transfer of the knowledge, skills and experiences in his/her area to the interdisciplinary applications.X
8Ability of evaluation and interpretation of data in scientific studies and oral and written presentation of results.X
9Ability to study in intra- and interdisciplinary teams effectively and to make leaadership in such teamsX
10Ability to bring an innovation/ to develop a new method and/or application of a known method to a new area.X
11Ability to determine the research areas such that meet the needs of society and industry and also to make contribution to the literature.X
12Ability to determine the scope, goals, pathway and ability to study in planned way for a scientific study.X
13Information about awareness of entrepreneurship, innovation, and sustainable development.X
14Ability to use of research results in technological applications and/or scientific research fields.X
15Ability to prepare, present and to design the national and international project proposal.X
16Awareness of professional and ethical responsibility.X
17Ability to make independent research and ability to interpretate scientific studies by a criticizing approach.X
18Ability to make an original study that can make contribution to the literature.X
19Knowledge about awareness of the legal consequences of carry out the scientifc reseraches and the publishing of the results.X
20Ability to interpret the studies written in a foreign language and to make presentation in a foreign language.X
 -- NAME OF LECTURER(S)
   (Prof. Dr. Figen Ünlü Erkoç)
 -- WEB SITE(S) OF LECTURER(S)
   (http://websitem.gazi.edu.tr/erkoc , http://www.websitem.gazi.edu.tr/site/erkoc/files)
 -- EMAIL(S) OF LECTURER(S)
   (erkoc@gazi.edu.tr)