GAZI UNIVERSITY INFORMATION PACKAGE - 2019 ACADEMIC YEAR

COURSE DESCRIPTION
T and B Receptor Variability Mechanism/İMM-3030
Course Title: T and B Receptor Variability Mechanism
Credits 2 ECTS 2
Semester 1 Compulsory/Elective Elective
COURSE INFO
 -- LANGUAGE OF INSTRUCTION
  Turkish
 -- NAME OF LECTURER(S)
  Prof. Dr. Ayşegül ATAK YÜCEL, MD, PhD
 -- WEB SITE(S) OF LECTURER(S)
  http://websitem.gazi.edu.tr/site/aysegula
 -- EMAIL(S) OF LECTURER(S)
  aysegula@yahoo.com
 -- LEARNING OUTCOMES OF THE COURSE UNIT
Learns the structures and functions of T and B lymphocyte receptors
Learns variability in T and B lymphocyte receptors and the mechanisms responsible for this variability
 -- MODE OF DELIVERY
  The mode of delivery of this course is face to face.
 -- PREREQUISITES AND CO-REQUISITES
  There is no prerequisite or co-requisite for this course.
 -- RECOMMENDED OPTIONAL PROGRAMME COMPONENTS
  Basic Immunology - I Basic Immunology - II Lymphocyte ontogenesis Lymphocyte development
 --COURSE CONTENT
1. Week  Antigen presentation and antigen presenting cells
2. Week  B cell antigen receptor, its structure,functions, and its signalling mechanisms
3. Week  T cell antigen receptor, its structure,functions, and its signalling mechanisms
4. Week  Why variability is necessary?
5. Week  How variability develops during lymphocyte ontogenesis and development? What is linkage disequilibrium?
6. Week  Overview before midterm
7. Week  Examination (Midterm)
8. Week  VDJ gene rearrangement for B cells
9. Week  VDJ gene rearrangement for T cells
10. Week  Terminal deoxynucleotidyl transferase (Tdt)and junctional diversity
11. Week  Rearrangement activating gene 1 (RAG1) and RAG2, Omenn's syndrome, Severe combined immunodeficiency (SCID
12. Week  Role of cytokines in T cell receptor variability (diversity)
13. Week  Role of cytokines in B cell receptor variability (diversity)
14. Week  Affinity maturation and avidity tets
15. Week  Overview
16. Week  Final examination
 -- RECOMMENDED OR REQUIRED READING
  aul WE. Fundamental Immunology, Merritt J, Seto J, Martin SP, Warnuck CJ, Jenny C (eds), 5th ed.Lippincott Williams and Wilkins Publishers.USA, 2003.
 -- PLANNED LEARNING ACTIVITIES AND TEACHING METHODS
  Lecture, Question & Answer, Student Presentation
 -- WORK PLACEMENT(S)
  None
 -- ASSESSMENT METHODS AND CRITERIA
 
Quantity
Percentage
 Mid-terms
1
30
 Assignment
1
20
 Exercises
0
0
 Projects
0
0
 Practice
0
0
 Quiz
1
50
 Contribution of In-term Studies to Overall Grade  
50
 Contribution of Final Examination to Overall Grade  
50
 -- WORKLOAD
 Efficiency  Total Week Count  Weekly Duration (in hour)  Total Workload in Semester
 Theoretical Study Hours of Course Per Week
14
2
28
 Practising Hours of Course Per Week
0
0
0
 Reading
4
1
4
 Searching in Internet and Library
4
1
4
 Designing and Applying Materials
3
2
6
 Preparing Reports
0
0
0
 Preparing Presentation
2
1
2
 Presentation
2
1
2
 Mid-Term and Studying for Mid-Term
1
2
2
 Final and Studying for Final
1
2
2
 Other
0
 TOTAL WORKLOAD: 
50
 TOTAL WORKLOAD / 25: 
2
 ECTS: 
2
 -- COURSE'S CONTRIBUTION TO PROGRAM
NO
 PROGRAM LEARNING OUTCOMES
1
2
3
4
5
1X
2X
3X
4X
5X
6X
7X
8X
9X
10X